E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1.

Induction of hypoxia-inducible factor-1α inhibits drug-induced apoptosis in the human leukemic cell line HL-60

BACKGROUND Leukemic cells originate from hypoxic bone marrow, which protects them from anti-cancer drugs. Although many factors that cause drug resistance in leukemic cells have been studied, the effect of hypoxia on drug-induced apoptosis is still poorly understood. METHODS In this study, we examined the effect of hypoxia on anti-leukemic drug resistance in leukemic cell lines treated with c...

Downregulation of Telomerase in CoCl2-Induced Apoptosis of Myeloid Leukemic Cells

Many reports showed that hypoxia-inducible factor-1 (HIF-1 ), the main factor activated by hypoxia, plays a role in the transcriptional regulation of the human telomerase reverse transcriptase (hTERT), one of the critical elements of the oncogenic process. As a hypoxia-mimetic agent, cobalt chloride (CoCl2) can induce the accumulation of HIF-1 . Herein, we demonstrated that hTERT expression was...

Molecular Mechanisms of Acclimatization to High Altitude Hypoxia: Role of Hypoxia Mimetic Cobalt Chloride

The hypoxia-mimetic agent cobalt chloride induces cell cycle arrest and alters gene expression in U266 multiple myeloma cells.

Hypoxia is a common feature of tumors that occurs across a wide variety of malignancies. Multiple myeloma is an incurable malignant disorder of plasma cells in the bone marrow. Although bone marrow hypoxia is crucial for normal hematopoiesis, the effect of hypoxia on multiple myeloma is poorly understood. In this study, we demonstrated that cobalt...

Effects of cobalt chloride on phenotypes of normal human saphenous vein smooth muscle cells.

To explore the cellular adaptations and responses to hypoxia in normal human saphenous vein smooth muscle cells (SMCs) and presume what roles phenotypic modulation of normal human saphenous vein SMCs would play in varicose vein of lower extremity, we used cobalt chloride (CoCl2), a hypoxia mimetic, to treat normal human saphenous vein SMCs in vitro. The proliferating ability of cells exposed to...